LRRK2-IN-1

Biological Activity for LRRK2-IN-1

Technical Data for LRRK2-IN-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LRRK2-IN-1

References for LRRK2-IN-1

References are publications that support the biological activity of the product.

• Chia R, Haddock S, Beilina A, Rudenko I, Mamais A, Kaganovich A, Li Y, Kumaran R, Nalls M, Cookson M Phosphorylation of LRRK2 by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nat Commun, 2014;5(0):5827. 2014 PMID: 25500533
• J Park, JW Lee, SC Cooper, HE Broxmeyer, JR Cannon, CH Kim Parkinson disease-associated LRRK2 G2019S transgene disrupts marrow myelopoiesis and peripheral Th17 response J. Leukoc. Biol., 2017;0(0):. 2017 PMID: 28751472
• Zhao et al. LRRK2 Dephosphorylation increases its ubiquitination. Biochem.J., 2015;469:107 PMID: 25939886
• Deng et al. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat.Chem.Biol., 2011;7:203 PMID: 21378983
• Thévenet et al. Regulation of LRRK2 expression points to a functional role in human monocyte maturation. PLoS One, 2011;6:e21519 PMID: 21738687