LU AA33810

Name: LU AA33810
Brand: Tocris Bioscience
SKU: 3562

Tocris Bioscience, part of Bio-Techne | Catalog # 3562

Citations (2)

COA / SDS

Potent NPY Y5 receptor antagonist

Key Product Details

Chemical Name:	N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide
Purity:	≥98%
Molecular Weight:	423.62 kDa

View Full Technical Details for LU AA33810

Technical Data
Citations

Biological Activity for LU AA33810

LU AA33810 is a potent neuropeptide Y (NPY) Y₅ receptor antagonist (K_i = 1.5 nM in vitro). Displays ≥ 3300-fold affinity for Y₅ over Y₁, Y₂ and Y₄ receptors. Also binds human 5-HT_2B and 5-HT_1A receptors (K_i values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.

Technical Data for LU AA33810

M. Wt	423.62 kDa
Formula	C₁₉H₂₅N₃O₂S₃
Storage	Store at RT
Purity	≥98%
CAS Number	304008-29-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LU AA33810

Solubility

Soluble Soluble to 100 mM in DMSO

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References for LU AA33810

References are publications that support the biological activity of the product.

Walker et al. The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects J.Pharmacol.Exp.Ther., 2009;328:900 PMID: 19098165