Luteolin

Name: Luteolin
Brand: Tocris Bioscience
SKU: 2874

Tocris Bioscience, part of Bio-Techne | Catalog # 2874

Citations (16)

COA / SDS

Anti-inflammatory, antioxidant and free radical scavenger

Key Product Details

Description:	Anti-inflammatory, antioxidant and free radical scavenger
Alternative Names:	3',4',5,7-Tetrahydroxyflavone
Chemical Name:	2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	286.24

View Full Technical Details for Luteolin

Technical Data
Citations

Biological Activity for Luteolin

Luteolin is an anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. Also inhibits TNF-α -induced COX-2 expression. Antiproliferative and chemopreventative; inhibits proliferation of Lewis lung carcinoma cells in vivo. Inhibits influenza virus replication in vitro by preventing viral entry. Molecular docking studies also indicate binding to SARS-CoV-2 main protease (M^pro or 3CL^pro).

Technical Data for Luteolin

M. Wt	286.24
Formula	C₁₅H₁₀O₆
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	491-70-3
PubChem ID	5280445
InChi Key	IQPNAANSBPBGFQ-UHFFFAOYSA-N
Smiles	O=C(C=C(C3=CC(O)=C(O)C=C3)O2)C1=C2C=C(O)C=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Luteolin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	1.43	5
	DMSO	14.31	50

Preparing Stock Solutions for Luteolin

The following data is based on the product molecular weight 286.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.99 mL	34.94 mL	69.87 mL
2.5 mM	1.40 mL	6.99 mL	13.97 mL
5 mM	0.70 mL	3.49 mL	6.99 mL
25 mM	0.14 mL	0.70 mL	1.40 mL

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References for Luteolin

References are publications that support the biological activity of the product.

Yu Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking. Int.J.Antimicrob.Agents 2020 PMID: 32389723
Yan Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression. J.Nat.Med. 2019 PMID: 30758716
Kim Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/ threonine kinase, inhibits tumor necrosis factor-α-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. J.Pharm.Exp.Ther. 2011 PMID: 21705614
Kim Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. Ann.N.Y.Acad.Sci. 2007 PMID: 17410645
Chen Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophage. Life Sci. 2007 PMID: 17977562
Ju A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-κB pathway and sensitization of apoptosis in lung cancer cells. Mol.Pharmacol. 2007 PMID: 17296806