LY 2603618

Name: LY 2603618
Brand: Tocris Bioscience
SKU: 6454

Tocris Bioscience, part of Bio-Techne | Catalog # 6454

Citations (1)

COA / SDS

Potent and selective Chk1 inhibitor

Key Product Details

Description:	Potent and selective Chk1 inhibitor
Chemical Name:	N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N'-(5-methyl-2-pyrazinyl)urea
Purity:	≥98% (HPLC)
Molecular Weight:	436.3

View Full Technical Details for LY 2603618

Technical Data
Citations

Biological Activity for LY 2603618

LY 2603618 is a potent and selective Chk1 inhibitor (IC₅₀ = 7 nM). Inhibits Chk1 autophosphorylation. Induces cell cycle arrest in the G₂/M phase and induces the DNA damage response in lung cancer cells. Inhibits growth of NSCLC xenografts in mice when administered in combination with Pemetrexed (Cat.No. 6185).

Compound Libraries for LY 2603618

LY 2603618 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LY 2603618

M. Wt	436.3
Formula	C₁₈H₂₂BrN₅O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	911222-45-2
PubChem ID	11955855
InChi Key	SYYBDNPGDKKJDU-ZDUSSCGKSA-N
Smiles	CC1=CN=C(C=N1)NC(NC2=C(C=C(C(Br)=C2)C)OC[C@@H]3CNCCO3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 2603618

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.73	20

Preparing Stock Solutions for LY 2603618

The following data is based on the product molecular weight 436.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.46 mL	57.30 mL	114.60 mL
1 mM	2.29 mL	11.46 mL	22.92 mL
2 mM	1.15 mL	5.73 mL	11.46 mL
10 mM	0.23 mL	1.15 mL	2.29 mL

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References for LY 2603618

References are publications that support the biological activity of the product.

Calvo Preclinical analyses and phase I evaluation of LY2603618 administered in combination with pemet. and cisp. in patients with advanced cancer. Invest.New Drugs 2014 PMID: 24942404
Wang The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis 2014 PMID: 24928205