LY 2886721 Hydrochloride

Name: LY 2886721 Hydrochloride
Brand: Tocris Bioscience
SKU: 7081

Tocris Bioscience, part of Bio-Techne | Catalog # 7081

Citations (1)

COA / SDS

Potent and selective β-secretase (BACE) inhibitor

Key Product Details

Description:	Potent and selective β-secretase (BACE) inhibitor
Chemical Name:	N-[3-[(4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	426.87

View Full Technical Details for LY 2886721 Hydrochloride

Technical Data
Citations

Biological Activity for LY 2886721 Hydrochloride

LY 2886721 Hydrochloride is a potent and selective β-secretase (BACE) inhibitor (IC₅₀ values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.

Compound Libraries for LY 2886721 Hydrochloride

LY 2886721 Hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LY 2886721 Hydrochloride

M. Wt	426.87
Formula	C₁₈H₁₆F₂N₄O₂S.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1262036-49-6
PubChem ID	50902942
InChi Key	JHHMCINLHBUFHB-GHDSXOKHSA-N
Smiles	[H][C@@]12COC[C@]1(C3=CC(NC(C4=CC=C(C=N4)F)=O)=CC=C3F)N=C(SC2)N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 2886721 Hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.69	100

Preparing Stock Solutions for LY 2886721 Hydrochloride

The following data is based on the product molecular weight 426.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.71 mL	23.43 mL
5 mM	0.47 mL	2.34 mL	4.69 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for LY 2886721 Hydrochloride

References are publications that support the biological activity of the product.

May The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs and humans. J.Neurosci. 2015 PMID: 25609634