LY 379268

Name: LY 379268
Brand: Tocris Bioscience
SKU: 2453

Tocris Bioscience, part of Bio-Techne | Catalog # 2453

Citations (114)

COA / SDS

Highly selective group II mGlu agonist

Key Product Details

Description:	Highly selective group II mGlu agonist
Chemical Name:	(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Purity:	≥99% (HPLC)
Molecular Weight:	187.15

View Full Technical Details for LY 379268

Technical Data
Citations

Biological Activity for LY 379268

LY 379268 is a highly selective group II mGlu receptor agonist (EC₅₀ values are 2.69 and 4.48 nM for hmGlu₂ and hmGlu₃ respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. LY379268 disodium salt also available.

Licensing Information

Sold under license from Eli Lilly and Company

Technical Data for LY 379268

M. Wt	187.15
Formula	C₇H₉NO₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	191471-52-0
PubChem ID	10197984
InChi Key	YASVRZWVUGJELU-MDASVERJSA-N
Smiles	[H][C@]12[C@]([C@H]2[C@@](O)=O)([H])[C@](N)([C@](O)=O)CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 379268

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.74	20
	1eq. NaOH	18.71	100

Preparing Stock Solutions for LY 379268

The following data is based on the product molecular weight 187.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.34 mL	26.72 mL	53.43 mL
5 mM	1.07 mL	5.34 mL	10.69 mL
10 mM	0.53 mL	2.67 mL	5.34 mL
50 mM	0.11 mL	0.53 mL	1.07 mL

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References for LY 379268

References are publications that support the biological activity of the product.

Bond Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo. J.Pharmacol.Exp.Ther. 2000 PMID: 10945827
Collado (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties. J.Med.Chem. 2002 PMID: 12166935
Bond LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia. Neurosci.Lett. 1999 PMID: 10515191