LY 456236 hydrochloride

Name: LY 456236 hydrochloride
Brand: Tocris Bioscience
SKU: 2390

Tocris Bioscience, part of Bio-Techne | Catalog # 2390

(1)

Citations (5)

COA / SDS

Selective mGlu1 antagonist

Key Product Details

Chemical Name:	6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride
Purity:	≥99%
Molecular Weight:	317.77 kDa

View Full Technical Details for LY 456236 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for LY 456236 hydrochloride

LY 456236 hydrochloride is a selective mGlu₁ receptor antagonist (IC₅₀ values are 143 nM and > 10 μM for mGlu₁ and mGlu₅ receptors respectively). Reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED₅₀ values of 28 and 16.3 mg/kg respectively.

Technical Data for LY 456236 hydrochloride

M. Wt	317.77 kDa
Formula	C₁₆H₁₅N₃O₂.HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	338736-46-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 456236 hydrochloride

Solubility

Soluble Soluble to 20 mM in DMSO

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References for LY 456236 hydrochloride

References are publications that support the biological activity of the product.

Shannon et al. Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. Neuropharmacology, 2005;49:188 PMID: 16011839
Bertorelli et al. Selective blockade of metabotropic glutamate subtype mGluR1 receptors induce anti-nociceptive effects. Neuropharmacology, 2005;49:231