m-Chlorophenylbiguanide hydrochloride

Name: m -Chlorophenylbiguanide hydrochloride
Brand: Tocris Bioscience
SKU: 0440

Tocris Bioscience, part of Bio-Techne | Catalog # 0440

Citations (4)

COA / SDS

Potent and selective 5-HT3 agonist

Key Product Details

Description:	Potent and selective 5-HT₃ agonist
Chemical Name:	1-(3-Chlorophenyl)biguanide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	248.11

View Full Technical Details for m-Chlorophenylbiguanide hydrochloride

Technical Data
Citations

Biological Activity for m-Chlorophenylbiguanide hydrochloride

m-Chlorophenylbiguanide hydrochloride is a prototypical potent and selective 5-HT₃ receptor agonist.

Technical Data for m-Chlorophenylbiguanide hydrochloride

M. Wt	248.11
Formula	C₈H₁₀ClN₅.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	2113-05-5
PubChem ID	2730228
InChi Key	FOWAIJYHRWFTHR-UHFFFAOYSA-N
Smiles	Cl.NC(=N)NC(=N)NC1=CC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for m-Chlorophenylbiguanide hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	24.81	100

Preparing Stock Solutions for m-Chlorophenylbiguanide hydrochloride

The following data is based on the product molecular weight 248.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.03 mL	20.15 mL	40.30 mL
5 mM	0.81 mL	4.03 mL	8.06 mL
10 mM	0.40 mL	2.02 mL	4.03 mL
50 mM	0.08 mL	0.40 mL	0.81 mL

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Reconstitution Calculator

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References for m-Chlorophenylbiguanide hydrochloride

References are publications that support the biological activity of the product.

Sepulveda The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT₃ receptors in N1E-115 neuroblastoma cells. Br.J.Pharmacol. 1991 PMID: 1797317
Kilpatrick 1-(m-Chlorophenyl)biguanide, a potent high affinity 5-HT₃ receptor agonist. Eur.J.Pharmacol. 1990 PMID: 2144822
Niemeyer and Lummis Different efficacy of specific agonists at 5-HT₃ receptor splice variants: the role of the extra six amino acid segment. Br.J.Pharmacol. 1998 PMID: 9517385
Boess 5HT₃ receptors in NG108-15 neuroblastoma X glioma cells: effect of the novel agonist 1-(m-chlorophenyl)biguanide. Neuropharmacology 1992 PMID: 1407396