M4K2163 dihydrochloride

Name: M4K2163 dihydrochloride
Brand: Tocris Bioscience
SKU: 7754

Tocris Bioscience, part of Bio-Techne | Catalog # 7754

COA / SDS

Potent and selective ALK2 inhibitor

Key Product Details

Description:	Potent and selective ALK2 inhibitor
Chemical Name:	1-[4-[5-(4-Fluoro-3,5-dimethoxyphenyl)-4-methyl-3-pyridinyl]phenyl]piperazine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	480.41

View Full Technical Details for M4K2163 dihydrochloride

Technical Data
Citations

Biological Activity for M4K2163 dihydrochloride

M4K2163 is a potent and selective activin receptor-like kinase 2 (ALK2) inhibitor (IC₅₀ values are 19 nM in vivo and 98 nM in vitro). Orally bioavailable and brain penetrant.

Technical Data for M4K2163 dihydrochloride

M. Wt	480.41
Formula	C₂₄H₂₆FN₃O₂.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2863635-04-3
InChi Key	HMNLQIQCOZETBK-UHFFFAOYSA-N
Smiles	FC1=C(OC)C=C(C2=CN=CC(C3=CC=C(N4CCNCC4)C=C3)=C2C)C=C1OC.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for M4K2163 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	48.04	100
	DMSO	48.04	100

Preparing Stock Solutions for M4K2163 dihydrochloride

The following data is based on the product molecular weight 480.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.41 mL	20.82 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for M4K2163 dihydrochloride

References are publications that support the biological activity of the product.

Rooney and Jones Recent advances in ALK2 inhibitors. ACS Omega 2021 PMID: 34423181
Smil Leveraging an open science drug discovery model to develop CNS-penetrant ALK2 inhibitors for the treatment of diffuse intrinsic pontine glioma. J.Med.Chem. 2020 PMID: 32787083