Marimastat

Name: Marimastat
Brand: Tocris Bioscience
SKU: 2631
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2631

(1)

Citations (93)

COA / SDS

Broad spectrum MMP inhibitor

Key Product Details

Description:	Broad spectrum MMP inhibitor
Alternative Names:	BB 2516,Marimistat
Chemical Name:	(2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
Purity:	≥99% (HPLC)
Molecular Weight:	331.41

View Full Technical Details for Marimastat

Technical Data
Citations / Reviews (1)

Biological Activity for Marimastat

Marimastat is a broad spectrum inhibitor of MMPs (IC₅₀ values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.

Technical Data for Marimastat

M. Wt	331.41
Formula	C₁₅H₂₉N₃O₅
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	154039-60-8
PubChem ID	119031
InChi Key	OCSMOTCMPXTDND-OUAUKWLOSA-N
Smiles	O=C(NO)[C@@H](O)[C@H]([C@](N[C@@H]([C@](C)(C)C)C(NC)=O)=O)CC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Marimastat

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.14	100

Preparing Stock Solutions for Marimastat

The following data is based on the product molecular weight 331.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.09 mL	30.17 mL
5 mM	0.60 mL	3.02 mL	6.03 mL
10 mM	0.30 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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Reconstitution Calculator

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References for Marimastat

References are publications that support the biological activity of the product.

Wada Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition. Clin.Exp.Metastasis 2003 PMID: 14524532
Bjornland Matrix metalloproteinases participate in osteosarcoma invasion. J.Surg.Res. 2005 PMID: 16083752
Rasmussen and McCann Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol.Ther. 1997 PMID: 9364582