Mdivi 1

Name: Mdivi 1
Brand: Tocris Bioscience
SKU: 3982

Tocris Bioscience, part of Bio-Techne | Catalog # 3982

Citations (18)

COA / SDS

Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

Key Product Details

Description:	Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis
Chemical Name:	3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
Purity:	≥98% (HPLC)
Molecular Weight:	353.22

View Full Technical Details for Mdivi 1

Technical Data
Citations

Biological Activity for Mdivi 1

Mdivi 1 is a selective inhibitor of dynamin GTPase (IC₅₀ = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Mdivi 1 inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. In cancer cell lines, Mdivi 1 reduces cell proliferation; in an animal model of ischemic retina Mdivi 1 treatment blocks apoptosis. In a cell model, Mdivi 1 protects against mutant huntington-induced damage and mitochondrial dysfunction. Mdivi 1 also inhibits autophagy and protects neurons from excitotoxicity.

Technical Data for Mdivi 1

M. Wt	353.22
Formula	C₁₅H₁₀C_l2N₂O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	338967-87-6
PubChem ID	3825829
InChi Key	NZJKEVWTYMOYOR-UHFFFAOYSA-N
Smiles	O=C2N(C3=C(Cl)C=C(Cl)C(OC)=C3)C(S)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mdivi 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.32	100

Preparing Stock Solutions for Mdivi 1

The following data is based on the product molecular weight 353.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.16 mL	28.31 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.42 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for Mdivi 1

References are publications that support the biological activity of the product.

Ruiz Mitochondrial division inhibitor 1 (mdivi-1) protects neurons against excitotoxicity through the modulation of mitochondrial function and intracellular Ca ²⁺ signaling. Front.Mol.Neurosci. 2018 PMID: 29386996
Manczak and Reddy Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease. Hum.Mol.Genet. 2015 PMID: 26464486
Park A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest.Ophthalmol Vis.Sci. 2011 PMID: 21372007
Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
Cassidy-Stone Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Develop.Cell
Lackner Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine. Chem.Biol. 2010 PMID: 20142041
Tanaka and Youle A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol.Cell 2008 PMID: 18313377