Mefloquine hydrochloride

Name: Mefloquine hydrochloride
Brand: Tocris Bioscience
SKU: 6819

Tocris Bioscience, part of Bio-Techne | Catalog # 6819

Citations (1)

COA / SDS

Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal

Key Product Details

Description:	Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal
Chemical Name:	(αS)-rel-α-(2R)-2-Piperidinyl-2,3-bis(trifluoromethyl-4-quinolinemethanol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	414.77

View Full Technical Details for Mefloquine hydrochloride

Technical Data
Citations

Biological Activity for Mefloquine hydrochloride

Mefloquine hydrochloride is a Cx36 and Cx50 gap channel blocker (IC₅₀ values are 0.3 and 1.1 μM, resepctively). Blocks gap junctional-coupling between interneurons in neocortical slices. Also antimalarial. Bind 80S ribosome of Plasmodium falciparum to inhibit protein synthesis. Improves survival in P berghei-infected mice. Additionally exhibits antischistosomal activity in vitro and in vivo. Exhibits antiviral activities against SARS-CoV-2 (IC₅₀ < 10 μM).

Compound Libraries for Mefloquine hydrochloride

Mefloquine hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Mefloquine hydrochloride

M. Wt	414.77
Formula	C₁₇H₁₆F₆N_2O.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	51773-92-3
PubChem ID	65329
InChi Key	WESWYMRNZNDGBX-YLCXCWDSSA-N
Smiles	[H][C@]1([C@H](C2=CC(C(F)(F)F)=NC3=C(C(F)(F)F)C=CC=C23)O)CCCCN1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mefloquine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	41.48	100
	DMSO	20.74	50

Preparing Stock Solutions for Mefloquine hydrochloride

The following data is based on the product molecular weight 414.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.05 mL	24.11 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Mefloquine hydrochloride

References are publications that support the biological activity of the product.

Jeon Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs. Antimicrob.Agents Chemother. 2020 PMID: 32366720
Ohnmacht Antimalarials. 7. Bis(trifluoromethyl)-α-(2-piperidyl)-4-quinolinemethanols. J.Med.Chem. 1971 PMID: 5115690
Wong Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Nat.Microbiol. 2017 PMID: 28288098
Cruikshank Potent block of Cx36 and Cx50 gap junction channels by meflo. Proc.Natl.Acad.Sci.U.S.A. 2004 PMID: 15297615
Pasche Early antischistosomal leads identified from in vitro and in vivo screening of the Medicines for Malaria Venture Pathogen Box. ACS Infect.Dis. 2019 PMID: 30398059