Melittin

Name: Melittin
Brand: Tocris Bioscience
SKU: 1193

Tocris Bioscience, part of Bio-Techne | Catalog # 1193

Citations (8)

COA / SDS

Inhibits Gs and stimulates Gi activity

Key Product Details

Description:	Inhibits G_s and stimulates G_iactivity
Purity:	≥95% (HPLC)
Molecular Weight:	2847

View Full Technical Details for Melittin

Technical Data
Citations

Biological Activity for Melittin

Melittin is a inhibits G_s and stimulates G_i activity. Inhibits protein kinase C and cAMP-dependent protein kinases. Na⁺/K⁺ ATPase inhibitor.

Technical Data for Melittin

M. Wt	2847
Formula	C₁₃₁H₂₂₉N₃₉O₃₁
Single Letter Sequence	GIGAVLKVLTTGLPALISWIKRKRQQ (Modification: Gln-26 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	20449-79-0
PubChem ID	16133648
InChi Key	VDXZNPDIRNWWCW-JFTDCZMZSA-N
Smiles	[H]NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Melittin

Solubility

Soluble to 1mg/ml in water

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References for Melittin

References are publications that support the biological activity of the product.

Mousli G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. TiPS 1990 PMID: 2122563
Raynor Membrane interactions of amphiphilic polypeptides mastoparan, melittin, plymixin B and cardiotoxin. J.Biol.Chem. 1991 PMID: 1847132
Fukushima Melittin, a metabostatic peptide inhibiting G_s activity. Peptides 1998 PMID: 9663445