Mepyramine maleate

Name: Mepyramine maleate
Brand: Tocris Bioscience
SKU: 0660

Tocris Bioscience, part of Bio-Techne | Catalog # 0660

Citations (25)

COA / SDS

Selective H1 inverse agonist

Key Product Details

Description:	Selective H₁ inverse agonist
Alternative Names:	Pyrilamine maleate
Chemical Name:	2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridine maleate
Molecular Weight:	401.46

View Full Technical Details for Mepyramine maleate

Technical Data
Citations

Biological Activity for Mepyramine maleate

Mepyramine maleate is a selective inverse agonist for the H₁ receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC₅₀ = -7.94) and intracellular calcium mobilization. Sequesters G_q/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

Technical Data for Mepyramine maleate

M. Wt	401.46
Formula	C₁₇H₂₃N₃O.C₄H₄O₄
Storage	Store at RT
CAS Number	59-33-6
PubChem ID	5284451
InChi Key	JXYWFNAQESKDNC-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.COC1=CC=C(CN(CCN(C)C)C2=CC=CC=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mepyramine maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	40.15	100
	DMSO	40.15	100

Preparing Stock Solutions for Mepyramine maleate

The following data is based on the product molecular weight 401.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.45 mL	24.91 mL
5 mM	0.50 mL	2.49 mL	4.98 mL
10 mM	0.25 mL	1.25 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for Mepyramine maleate

References are publications that support the biological activity of the product.

Hill Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 1990 PMID: 2164693
Liu Does the [³H] mepyramine binding site represent the histamine H₁ receptor? Re-examination of the histamine H₂ receptor with qine J.Pharmacol.Exp.Ther. 1994 PMID: 8114011
Carlos Mepyramine, a histamine H₁ receptor inverse agonist, binds perferentially to a G protein-coupled form of the receptor and sequesters G protein. J.Biol.Chem. 2004 PMID: 15192105