Mexiletine hydrochloride

Name: Mexiletine hydrochloride
Brand: Tocris Bioscience
SKU: 2596

Tocris Bioscience, part of Bio-Techne | Catalog # 2596

Citations (3)

COA / SDS

Na+ channel blocker; antiarrhythmic agent

Key Product Details

Chemical Name:	1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride
Purity:	≥99%
Molecular Weight:	215.72 kDa

View Full Technical Details for Mexiletine hydrochloride

Technical Data
Citations

Biological Activity for Mexiletine hydrochloride

Mexiletine hydrochloride is an use-dependent sodium channel blocker (IC₅₀ values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.

Technical Data for Mexiletine hydrochloride

M. Wt	215.72 kDa
Formula	C₁₁H₁₇NO.HCl
Storage	Desiccate at +4°C
Purity	≥99%
CAS Number	5370-01-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mexiletine hydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for Mexiletine hydrochloride

References are publications that support the biological activity of the product.

Franchini et al. Optically active mexil. analogues as stereoselective blockers of voltage-gated Na⁺ channels. J.Med.Chem., 2003;46:5238 PMID: 14613326
Ates et al. Neuroprotective effect of mexil. in the central nervous system of diabetic rats. Mol.Cell.Biochem., 2006;286:125 PMID: 16541198
Bellis et al. Evaluation of the pharmacological activity of the major mexil. metabolites on skeletal muscle sodium currents. Br.J.Pharmacol., 2006;149:300 PMID: 16921388