MG 132

Biological Activity for MG 132

Technical Data for MG 132

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MG 132

References for MG 132

References are publications that support the biological activity of the product.

• HJ Wobst, L Delsing, NJ Brandon, SJ Moss Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant PLoS ONE, 2017;12(5):e0177181. 2017 PMID: 28510586
• Ma Y, Yuan X, Wyatt WR Expression of constitutively active CDK1 stabilizes APC-Cdh1 substrates and potentiates premature spindle assembly and checkpoint function in G1 cells. PLoS ONE, 2012;7(3):e33835. 2012 PMID: 22479455
• Gupta N, Li W, Willard B, Silverstein R, McIntyre T Proteasome proteolysis supports stimulated platelet function and thrombosis. Arterioscler Thromb Vasc Biol, 2014;34(1):160-8. 2014 PMID: 24177323
• Lang SM, Kazi AA, Hong-Brown L, Lang CH Delayed Recovery of Skeletal Muscle Mass following Hindlimb Immobilization in mTOR Heterozygous Mice. PLoS ONE, 2012;7(6):e38910. 2012 PMID: 22745686
• Hoss, Andrew G, Kartha, Vinay K, Dong, Xianjun, Latourelle, Jeanne C, Dumitriu, Alexandr, Hadzi, Tiffany, Macdonald, Marcy E, Gusella, James F, Akbarian, Schahram, Chen, Jiang-Fa, Weng, Zhiping, Myers, Richard MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis. PLoS Genet, 2014;10(2):e1004188. 2014 PMID: 24586208
• Tran H, Polakis P Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the beta-catenin destruction complex. J Biol Chem, 2012;287(34):28552-63. 2012 PMID: 22761442
• Lin, Kai-Ti, Yeh, Yu-Ming, Chuang, Chi-Mu, Yang, Scarlett, Chang, Jer-Wei, Sun, Shu-Pin, Wang, Yi-Shian, Chao, Kuan-Cho, Wang, Lu-Hai Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B. Nat Commun, 2015;6(0):5917. 2015 PMID: 25569036
• Blount JR, Burr AA, Denuc A Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation. PLoS ONE, 2012;7(5):e36542. 2012 PMID: 22590560
• M Lötzerich, PS Roulin, K Boucke, R Witte, O Georgiev, UF Greber Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death Cell Death Dis, 2018;9(3):272. 2018 PMID: 29449668
• Morris L, Hartman I, Jun D, Seemann J, Debose-Boyd R Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, endoplasmic reticulum (ER)-associated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem, 2014;289(27):19053-66. 2014 PMID: 24860107
• Y Gao, H Zhang, L Luo, J Lin, D Li, S Zheng, H Huang, S Yan, J Yang, Y Hao, H Li, F Gao Smith, S Jin Resolvin D1 Improves the Resolution of Inflammation via Activating NF-?B p50/p50-Mediated Cyclooxygenase-2 Expression in Acute Respiratory Distress Syndrome J. Immunol., 2017;0(0):. 2017 PMID: 28794232
• Hough C, Radu M, Dore J Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling. PLoS ONE, 2012;7(8):e42513. 2012 PMID: 22880011
• Banerjee and Liefshitz Potential of the proteasome inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res., 2001;21:3941 PMID: 11911275
• Palombella et al. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell, 1994;78:773 PMID: 8087845
• Tsubuki et al. Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-Leucine and tri-Leucine. J.Biochem., 1996;119:572 PMID: 8830056
• Ma et al. Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell Res., 2020; PMID: 32541865
• Douar et al. Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradation J.Virol., 2001;75:1824 PMID: 11160681