Mifepristone

Name: Mifepristone
Brand: Tocris Bioscience
SKU: 1479

Tocris Bioscience, part of Bio-Techne | Catalog # 1479

Citations (50)

COA / SDS

Progesterone and glucocorticoid receptor antagonist

Key Product Details

Description:	Progesterone and glucocorticoid receptor antagonist
Alternative Names:	RU 486,RU 38486
Chemical Name:	(11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one
Purity:	≥99% (HPLC)
Molecular Weight:	429.6

View Full Technical Details for Mifepristone

Technical Data
Citations

Biological Activity for Mifepristone

Mifepristone is a selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo. Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone (Cat. No. 1126).

Compound Libraries for Mifepristone

Mifepristone is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Mifepristone

M. Wt	429.6
Formula	C₂₉H₃₅NO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	84371-65-3
PubChem ID	55245
InChi Key	VKHAHZOOUSRJNA-GCNJZUOMSA-N
Smiles	[H][C@@]23CCC1=CC(CCC1=C2[C@@H]([C@]5=CC=C(N(C)C)C=C5)C[C@@]4(C)[C@]([H])3CC[C@@](C#CC)4O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mifepristone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.96	100
	ethanol	21.48	50 with gentle warming

Preparing Stock Solutions for Mifepristone

The following data is based on the product molecular weight 429.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.64 mL	23.28 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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Reconstitution Calculator

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References for Mifepristone

References are publications that support the biological activity of the product.

Mao Molecular mechanism of RU 486 action: a review. Mol.Cell.Biochem. 1992 PMID: 1614417
Schrieber Binding of the anti-progestin RU 486 to rat ovary steroid receptors. Contraception 1983 PMID: 6627946
Gagne RU 38486: a potent antiglucocorticoid in vitro and in vivo. J.Steroid Biochem. 1985 PMID: 2864478