Miglitol

Name: Miglitol
Brand: Tocris Bioscience
SKU: 4985

Tocris Bioscience, part of Bio-Techne | Catalog # 4985

COA / SDS

α-glucosidase inhibitor

Discontinued Product

4985 has been discontinued. View all Glycosylase Inhibitors products.

Key Product Details

Description:	α-glucosidase inhibitor
Alternative Names:	Bay m1009
Chemical Name:	(2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(2-hydroxymethyl)-3,4,5-piperidinetriol
Purity:	≥98% (HPLC)
Molecular Weight:	207.22

View Full Technical Details for Miglitol

Technical Data
Citations

Biological Activity for Miglitol

Miglitol is an inhibitor of α-glucosidase; antihyperglycemic. Suppresses postprandial hyperglycemia in vivo and reduces plasma glucose concentration in normal rats and in several animal models of diabetes. Shown to inhibit the loss of pancreatic β cells in type 2 diabetic rats. Also inhibits apoptosis and mitochondrial overproduction of reactive oxygen species in endothelial cells in vitro.

Compound Libraries for Miglitol

Miglitol is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Miglitol

M. Wt	207.22
Formula	C₈H₁₇NO₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	72432-03-2
PubChem ID	441314
InChi Key	IBAQFPQHRJAVAV-ULAWRXDQSA-N
Smiles	OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Miglitol

References are publications that support the biological activity of the product.

Goda Effects of miglitol, an α-glucosidase inhibitor, on glycaemic staus and histopathological changes in islets in non-obese, non-Ins-dependent diabetic Goto-Kakizaki rats. Br.J.Nutr. 2007 PMID: 17537288
Sels Miglitol, a new α-glucosidase inhibitor. Expert.Opin.Pharmacother. 1999 PMID: 11249557
Aoki Miglitol, an anti-diabetic drug, inhibits oxdiative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. J.Pharmacol.Sci. 2012 PMID: 23018899