(-)-Xestospongin C

Name: (-)-Xestospongin C
Brand: Tocris Bioscience
SKU: 1280
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1280

(3)

Citations (119)

COA / SDS

Reported inhibitor of IP3-dependent Ca2+ release

Key Product Details

Description:	Reported inhibitor of IP₃-dependent Ca²⁺ release
Alternative Names:	XeC
Chemical Name:	(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine
Molecular Weight:	446.71

View Full Technical Details for (-)-Xestospongin C

Technical Data
Citations / Reviews (3)

Biological Activity for (-)-Xestospongin C

(-)-Xestospongin C is a reported inhibitor of IP₃-dependent Ca²⁺ release. Inhibits bradykinin-induced Ca²⁺ release in PC12 cells and attenuates PHP-induced IL-2 production in Jurkat T cells. Exhibits no effect on ryanodine receptor-mediated Ca²⁺ release in PC12 cells and shows no apparent interaction with the IP₃ binding site. Other subsequent reports show (-)-Xestospongin C to be ineffective as an antagonist of IP₃-evoked Ca²⁺ release in IP₃ recepto- expressing DT40 cells. Cell permeable.

NOTE: (-)-Xestospongin C is typically used at a final concentration ranging from 0.5 to 10 μM. It is recommended to prepare stock solutions (10x to 100x) in DMSO or ethanol.

Technical Data for (-)-Xestospongin C

M. Wt	446.71
Formula	C₂₈H₅₀N₂O₂
Storage	Store at -20°C
CAS Number	88903-69-9
PubChem ID	9846431
InChi Key	PQYOPBRFUUEHRC-HCKQMYSWSA-N
Smiles	[H][C@]12[C@@H](CCCCCC[C@@H]3CCN(CCC[C@H]4CCCCCC5)[C@@]4([H])O3)CCCN1CC[C@@H]5O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for (-)-Xestospongin C

References are publications that support the biological activity of the product.

Saleem Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP₃) receptor. Br.J.Pharmacol. 2014 PMID: 24628114
Ozaki Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle. Br.J.Pharmacol. 2002 PMID: 12466229
Dadsetan Store-operated Ca²⁺ influx causes Ca²⁺ release from the intracellular Ca²⁺ channels that is required for T cell activation. J.Biol.Chem. 2008 PMID: 18316371
Gafni Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron 1997 PMID: 9331361

(-)-Xestospongin C

Tocris Bioscience, part of Bio-Techne | Catalog # 1280

Key Product Details

Biological Activity for (-)-Xestospongin C

Technical Data for (-)-Xestospongin C

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for (-)-Xestospongin C

Product Documents for (-)-Xestospongin C

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected