Mirtazapine

Name: Mirtazapine
Brand: Tocris Bioscience
SKU: 2018

Tocris Bioscience, part of Bio-Techne | Catalog # 2018

Citations (378)

COA / SDS

Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant

Key Product Details

Description:	Potent 5-HT₂ antagonist; also 5-HT₃, H₁ and α₂ antagonist; antidepressant
Alternative Names:	Org 3770,6-Azamianserin
Chemical Name:	1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Purity:	≥99% (HPLC)
Molecular Weight:	265.36

View Full Technical Details for Mirtazapine

Technical Data
Citations

Biological Activity for Mirtazapine

Mirtazapine is an antidepressant agent; potent 5-HT₂, 5-HT₃ and histamine H₁ receptor antagonist and moderately potent α₂-adrenoceptor antagonist (pK_i values are 8.05, ~ 8.1, 9.3 and 6.95 respectively). Enhances noradrenaline (NA) release in rat brain via inhibition of α₂-adrenergic autoreceptors and displays only weak affinity for monoamine transporters (pK_i values are 5.6, < 5 and < 5.1 for inhibition of NA, dopamine and 5-HT uptake respectively). Increases hippocampal NA and 5-HT levels in rats following systemic administration in vivo.

Compound Libraries for Mirtazapine

Mirtazapine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Mirtazapine

M. Wt	265.36
Formula	C₁₇H₁₉N₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	85650-52-8
PubChem ID	4205
InChi Key	RONZAEMNMFQXRA-UHFFFAOYSA-N
Smiles	CN1CCN2C(C1)C1=CC=CC=C1CC1=C2N=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mirtazapine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	13.27	50
	DMSO	5.31	20

Preparing Stock Solutions for Mirtazapine

The following data is based on the product molecular weight 265.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.54 mL	37.68 mL	75.37 mL
2.5 mM	1.51 mL	7.54 mL	15.07 mL
5 mM	0.75 mL	3.77 mL	7.54 mL
25 mM	0.15 mL	0.75 mL	1.51 mL

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References for Mirtazapine

References are publications that support the biological activity of the product.

Kooyman Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells. Neuropharmacology 1994 PMID: 7984289
de Boer Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazepine, mianserin and idazoxan. J.Pharmacol.Exp.Ther. 1996 PMID: 8627567
de Boer Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, ORG 3770 and its enantiomers. Neuropharmacology 1988 PMID: 3419539