Misoprostol

Name: Misoprostol
Brand: Tocris Bioscience
SKU: 2297

Tocris Bioscience, part of Bio-Techne | Catalog # 2297

Citations (6)

COA / SDS

Cytoprotective PGE1 analog

Discontinued Product

2297 has been discontinued. View all Prostanoid Receptor Agonists products.

Key Product Details

Description:	Cytoprotective PGE₁ analog
Chemical Name:	(±)-(11a,13E)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oic acid methyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	382.53

View Full Technical Details for Misoprostol

Technical Data
Citations

Biological Activity for Misoprostol

Misoprostol is a cytoprotective prostaglandin E₁ analog that displays agonist activity at EP receptors. K_i values are 120, 250, 67 and 67 nM at cloned mouse EP₁, EP₂, EP₃ and EP₄ receptors respectively. Prevents NSAID-induced gastric ulceration.

Technical Data for Misoprostol

M. Wt	382.53
Formula	C₂₂H₃₈O₅
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	59122-46-2
PubChem ID	5282381
InChi Key	OJLOPKGSLYJEMD-URPKTTJQSA-N
Smiles	O[C@@H]1CC([C@H](CCCCCCC(OC)=O)[C@H]1/C=C/CC(O)(C)CCCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Misoprostol

References are publications that support the biological activity of the product.

Smith Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosus. J.Pharmacol.Exp.Ther. 1994 PMID: 7965740
Kiriyama Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 1997 PMID: 9313928
Graham Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. Lancet 1988 PMID: 2904006

Product Documents for Misoprostol

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Misoprostol, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov