Misoprostol

Name: Misoprostol
Brand: Tocris Bioscience
SKU: 2297

Tocris Bioscience, part of Bio-Techne | Catalog # 2297

Citations (6)

COA / SDS

Cytoprotective PGE1 analog

Key Product Details

Chemical Name:	(±)-(11a,13E)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oic acid methyl ester
Purity:	≥99%
Molecular Weight:	382.53 kDa

View Full Technical Details for Misoprostol

Technical Data
Citations

Biological Activity for Misoprostol

Misoprostol is a cytoprotective prostaglandin E₁ analog that displays agonist activity at EP receptors. K_i values are 120, 250, 67 and 67 nM at cloned mouse EP₁, EP₂, EP₃ and EP₄ receptors respectively. Prevents NSAID-induced gastric ulceration.

Technical Data for Misoprostol

M. Wt	382.53 kDa
Formula	C₂₂H₃₈O₅
Storage	Desiccate at -20°C
Purity	≥99%
CAS Number	59122-46-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Misoprostol

Solubility

Soluble Soluble to 100 mM in ethanol and to 100 mM in DMSO

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References for Misoprostol

References are publications that support the biological activity of the product.

Graham et al. Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. Lancet, 1988;2:1277 PMID: 2904006
Smith et al. Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosus. J.Pharmacol.Exp.Ther., 1994;271:390 PMID: 7965740
Kiriyama et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol., 1997;122:217 PMID: 9313928

Product Documents for Misoprostol

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Misoprostol, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov