Mitoxantrone dihydrochloride

Name: Mitoxantrone dihydrochloride
Brand: Tocris Bioscience
SKU: 4250
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4250

(1)

Citations (2)

COA / SDS

Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent

Discontinued Product

4250 has been discontinued. View all DNA Topoisomerase Inhibitors products.

Key Product Details

Description:	Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent
Chemical Name:	1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	517.4

View Full Technical Details for Mitoxantrone dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Mitoxantrone dihydrochloride

Mitoxantrone dihydrochloride is a type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC₅₀ = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC₅₀= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.

Technical Data for Mitoxantrone dihydrochloride

M. Wt	517.4
Formula	C₂₂H₂₈N₄O₆.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	70476-82-3
PubChem ID	51082
InChi Key	ZAHQPTJLOCWVPG-UHFFFAOYSA-N
Smiles	O=C2C3=C(C(O)=CC=C3O)C(C1=C(NCCNCCO)C=CC(NCCNCCO)=C12)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Mitoxantrone dihydrochloride

References are publications that support the biological activity of the product.

Burkhart Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival. Mol.Cancer Res. 2013 PMID: 23696131
Crespi Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochem.Biophys.Res.Comm. 1986 PMID: 3010982
Wan A new target for an old drug: identifying mitoxan. as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J.Med.Chem. 2013 PMID: 23442188
Scott and Figgit Mitoxantrone: a review of its uses in multiple sclerosis. CNS Drugs. 2004 PMID: 15089110

Product Documents for Mitoxantrone dihydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Mitoxantrone hydrochloride, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov