ML 418

Name: ML 418
Brand: Tocris Bioscience
SKU: 6889

Tocris Bioscience, part of Bio-Techne | Catalog # 6889

COA / SDS

Kir 7.1 inhibitor; also inhibits Kir 6.2

Key Product Details

Description:	K_ir 7.1 inhibitor; also inhibits K_ir 6.2
Chemical Name:	Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	377.87

View Full Technical Details for ML 418

Technical Data
Citations

Biological Activity for ML 418

ML 418 is a K_ir7.1 inhibitor (IC₅₀ = 0.31 μM). Also inhibits K_ir6.2 with similar potency. Displays >17-fold selectivity for K_ir7.1 over K_ir1.1, K_ir2.1, K_ir2.2, K_ir2.3, K_ir3.1/3.2 and K_ir4.1. Active in vivo.

Compound Libraries for ML 418

ML 418 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 418

M. Wt	377.87
Formula	C₁₉H₂₄CIN₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1928763-08-9
PubChem ID	91667465
InChi Key	CWIXCQOSULUGBT-UHFFFAOYSA-N
Smiles	CC(OC(NC1CCN(CC1)CC2=C(C3=C(C(Cl)=C2)C=CC=N3)O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 418

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.56	20

Preparing Stock Solutions for ML 418

The following data is based on the product molecular weight 377.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.23 mL	66.16 mL	132.32 mL
1 mM	2.65 mL	13.23 mL	26.46 mL
2 mM	1.32 mL	6.62 mL	13.23 mL
10 mM	0.26 mL	1.32 mL	2.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for ML 418

References are publications that support the biological activity of the product.

Kharade Pore polarity and charge determine differential block of K_ir1.1 and K_ir7.1 potassium channels by small-molecule inhibitor VU590. Mol.Pharmacol. 2017 PMID: 28619748
Swale ML418: the first selective, sub-micromolar pore blocker of K_ir7.1 potassium channels. ACS Chem.Neurosci. 2016 PMID: 27184474