ML 7 hydrochloride

Name: ML 7 hydrochloride
Brand: Tocris Bioscience
SKU: 4310
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4310

(2)

Citations (18)

COA / SDS

Selective inhibitor of myosin light chain kinase

Key Product Details

Description:	Selective inhibitor of myosin light chain kinase
Chemical Name:	Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	452.74

View Full Technical Details for ML 7 hydrochloride

Technical Data
Citations / Reviews (2)

Biological Activity for ML 7 hydrochloride

ML 7 hydrochloride is a selective MLCK inhibitor (K_i= 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca²⁺-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.

Technical Data for ML 7 hydrochloride

M. Wt	452.74
Formula	C₁₅H₁₇IN₂O₂S.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	110448-33-4
PubChem ID	9803932
InChi Key	KDDALCDYHZIZMH-UHFFFAOYSA-N
Smiles	IC1=C(C=CC=C2S(N3CCCNCC3)(=O)=O)C2=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 7 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.64	50

Preparing Stock Solutions for ML 7 hydrochloride

The following data is based on the product molecular weight 452.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.42 mL	22.09 mL	44.18 mL
2.5 mM	0.88 mL	4.42 mL	8.84 mL
5 mM	0.44 mL	2.21 mL	4.42 mL
25 mM	0.09 mL	0.44 mL	0.88 mL

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References for ML 7 hydrochloride

References are publications that support the biological activity of the product.

Meinders Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. Blood 2015 PMID: 25538045
Saitoh Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J.Biol.Chem. 1987 PMID: 3108259