MO-I-500

Name: MO-I-500
Brand: Tocris Bioscience
SKU: 6871

Tocris Bioscience, part of Bio-Techne | Catalog # 6871

COA / SDS

FTO inhibitor; anticonvulsant

Key Product Details

Description:	FTO inhibitor; anticonvulsant
Chemical Name:	N-[5-(4-Chlorophenyl)-3,4-dihydroxy-2-furanyl]ethanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	317.75

View Full Technical Details for MO-I-500

Technical Data
Citations

Biological Activity for MO-I-500

MO-I-500 is a FTO inhibitor (IC₅₀ = 8.7 μM for purified FTO in vitro), which increases N⁶-methyladenosine (m6A) levels in total cellular mRNA in HeLa cells. MO-I-500 modulates levels of specific miRNAs. In a triple-negative breast cancer cell line metabolically challenged by culture without glutamine (SUM149-MA cells), MO-I-500 inhibits cell proliferation. MO-I-500 also displays anticonvulsant activity in a 6 Hz mouse model of epilepsy at nontoxic doses.

Compound Libraries for MO-I-500

MO-I-500 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MO-I-500

M. Wt	317.75
Formula	C₁₂H₁₂ClNO₅S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1585219-04-0
PubChem ID	73505416
InChi Key	WWHUSZQHRUNRSB-UHFFFAOYSA-N
Smiles	CCS(=O)(NC1=C(C(O)=C(C2=CC=C(C=C2)Cl)O1)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MO-I-500

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.77	100

Preparing Stock Solutions for MO-I-500

The following data is based on the product molecular weight 317.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.74 mL	31.47 mL
5 mM	0.63 mL	3.15 mL	6.29 mL
10 mM	0.31 mL	1.57 mL	3.15 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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References for MO-I-500

References are publications that support the biological activity of the product.

Singh Important role of FTO in the survival of rare panresistant triple-negative inflammatory breast cancer cells facing a severe metabolic challenge. PLoS One. 2016 PMID: 27390851
Zheng Synthesis of a FTO inhibitor with anticonvulsant activity. ACS.Chem.Neurosci. 2014 PMID: 24834807