MOG (35-55)

Name: MOG (35-55)
Brand: Tocris Bioscience
SKU: 2568

Tocris Bioscience, part of Bio-Techne | Catalog # 2568

Citations (12)

COA / SDS

Encephalitogenic myelin oligodendrocyte glycoprotein fragment

Key Product Details

Purity:	≥95%
Molecular Weight:	2581.97 kDa

View Full Technical Details for MOG (35-55)

Technical Data
Citations

Biological Activity for MOG (35-55)

MOG (35-55) or myelin oligodendrocyte glycoprotein (MOG) 35-55 is a minor component of CNS myelin. MOG (35-55) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination, common to the manifestations of multiple sclerosis. MOG (35-55) induces strong T and B cell responses and is highly encephalitogenic. MOG (35-55) induces T cell-mediated multiple sclerosis in animal models. When co-administered with ITE, MOG (35-55) induces tolerogenic dendritic cells and suppresses disease development in mouse preclinical models of multiple sclerosis.

Technical Data for MOG (35-55)

M. Wt	2581.97 kDa
Formula	C₁₁₈H₁₇₇N₃₅O₂₉S
Storage	Store at -20°C
Purity	≥95%
CAS Number	149635-73-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MOG (35-55)

Solubility

Soluble Soluble to 0.50 mg/ml in water

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References for MOG (35-55)

References are publications that support the biological activity of the product.

J Chen, R He, W Sun, R Gao, Q Peng, L Zhu, Y Du, X Ma, X Guo, H Zhang, C Tan, J Wang, W Zhang, X Weng, J Man, H Bauer, QK Wang, BN Martin, CJ Zhang, X Li, C Wang TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response Nat Commun, 2020;11(1):1913. 2020 PMID: 32312989
Ichikawa et al. Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55. J.Immunol., 1996;157:919 PMID: 8752946
Slavin et al. Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein. Autoimmunity, 1998;28:109 PMID: 9771980
Zhang et al. T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6xSJL) F1 mice. J.Neuroimmunol., 2004;148:1 PMID: 14975581