Montelukast sodium

Name: Montelukast sodium
Brand: Tocris Bioscience
SKU: 5904

Tocris Bioscience, part of Bio-Techne | Catalog # 5904

Citations (3)

COA / SDS

CysLT1 and GPR17 antagonist

Key Product Details

Description:	CysLT₁ and GPR17 antagonist
Chemical Name:	1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt
Purity:	≥99% (HPLC)
Molecular Weight:	608.17

View Full Technical Details for Montelukast sodium

Technical Data
Citations

Biological Activity for Montelukast sodium

Montelukast sodium is a cysteinyl leukotriene receptor 1 (CysLT₁) and GPR17 antagonist. Blocks pentylenetetrazole-induced seizures, blood brain barrier (BBB) disruption and leukocyte migration in mice. Reduces neuroinflammation, improves BBB integrity, enhances learning and memory, and restores hippocampal neurogenesis and cognitive function in aged rats. Orally active and brain penetrant.

Compound Libraries for Montelukast sodium

Montelukast sodium is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Montelukast sodium

M. Wt	608.17
Formula	C₃₅H₃₅ClNNaO₃S
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	151767-02-1
PubChem ID	23663996
InChi Key	LBFBRXGCXUHRJY-HKHDRNBDSA-M
Smiles	CC(O)(C1=C(C=CC=C1)CC[C@H](C2=CC(/C=C/C3=NC4=CC(Cl)=CC=C4C=C3)=CC=C2)SCC5(CC5)CC(O[Na])=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Montelukast sodium

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	30.41	50
	DMSO	60.82	100

Preparing Stock Solutions for Montelukast sodium

The following data is based on the product molecular weight 608.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.64 mL	8.22 mL	16.44 mL
5 mM	0.33 mL	1.64 mL	3.29 mL
10 mM	0.16 mL	0.82 mL	1.64 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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References for Montelukast sodium

References are publications that support the biological activity of the product.

Marschallinger Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat.Commun. 2015 PMID: 26506265
Lenz Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction. Neuroscience 2014 PMID: 25090924