Pentylenetetrazole

Name: Pentylenetetrazole
Brand: Tocris Bioscience
SKU: 2687

Tocris Bioscience, part of Bio-Techne | Catalog # 2687

(1)

Citations (7)

COA / SDS

CNS stimulant

Key Product Details

Chemical Name:	6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine
Purity:	≥99%
Molecular Weight:	138.17 kDa

View Full Technical Details for Pentylenetetrazole

Technical Data
Citations / Reviews (1)

Biological Activity for Pentylenetetrazole

Pentylenetetrazole is a cNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.

Technical Data for Pentylenetetrazole

M. Wt	138.17 kDa
Formula	C₆H₁₀N₄
Storage	Store at -20°C
Purity	≥99%
CAS Number	54-95-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pentylenetetrazole

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Pentylenetetrazole

References are publications that support the biological activity of the product.

Hartman A, Santos P, Dolce A, Hardwick J The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice. PLoS ONE, 2012;7(9):e45156. 2012 PMID: 22984623
Rocha et al. Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res., 1996;26:105 PMID: 8985692
Walsh et al. Acute pentylenetetrazol injection reduces rat GABA_A receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J.Pharmacol.Exp.Ther., 1999;289:1626 PMID: 10336561
Dhir et al. Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog.Neuro-Psychopharm.Biol.Psychiat., 2006;30:1478