MPP dihydrochloride

Name: MPP dihydrochloride
Brand: Tocris Bioscience
SKU: 1991
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1991

Citations (125)

COA / SDS

Highly selective ERα antagonist

Key Product Details

Description:	Highly selective ERα antagonist
Chemical Name:	1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	542.5

View Full Technical Details for MPP dihydrochloride

Technical Data
Citations

Biological Activity for MPP dihydrochloride

MPP dihydrochloride is a selective, high affinity silent antagonist at ERα receptors. Displays > 200-fold selectivity for ERα over ERβ. K_i values are 2.7 and 1800 nM at ERα and ERβ receptors respectively.

Compound Libraries for MPP dihydrochloride

MPP dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MPP dihydrochloride

M. Wt	542.5
Formula	C₂₉H₃₁N₃O₃.2HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	911295-24-4
PubChem ID	45073474
InChi Key	SMPRQALBFACGGO-UHFFFAOYSA-N
Smiles	OC(C=C4)=CC=C4N1C(C(C=C3)=CC=C3OCCN2CCCCC2)=C(C)C(C5=CC=C(O)C=C5)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MPP dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	54.25	100

Preparing Stock Solutions for MPP dihydrochloride

The following data is based on the product molecular weight 542.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.84 mL	9.22 mL	18.43 mL
5 mM	0.37 mL	1.84 mL	3.69 mL
10 mM	0.18 mL	0.92 mL	1.84 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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Reconstitution Calculator

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References for MPP dihydrochloride

References are publications that support the biological activity of the product.

Sun Antagonists selective for estrogen receptor α. Endocrinol. 2002 PMID: 11861516
Harrington Activities of estrogen receptor alpha- and beta-selective ligands at diverse responsive gene sites mediating transactivation or transrepression. Mol.Cell.Endocrinol. 2003 PMID: 12943986