Mpro 61

Name: Mpro 61
Brand: Tocris Bioscience
SKU: 7695

Tocris Bioscience, part of Bio-Techne | Catalog # 7695

Citations (1)

COA / SDS

Potent non-covalent inhibitor of SARS-CoV-2 main protease

Key Product Details

Description:	Potent non-covalent inhibitor of SARS-CoV-2 main protease
Chemical Name:	5-[5-[3-Chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl]-6-oxo[1(6H),3'-bipyridin]-3-yl]-1-methyl-2,4(1H,3H)-pyrimidinedione
Purity:	≥95% (HPLC)
Molecular Weight:	565.38

View Full Technical Details for Mpro 61

Technical Data
Citations

Biological Activity for Mpro 61

Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease (IC₅₀ = 44 nM, EC₅₀ = 0.175 μM in the replicon assay and EC₅₀ = 0.08 μM in the infectious SARS-CoV-2 assay); it is cell permable and exhibits no apparent cytotoxicity.

Licensing Information

Sold under license from Yale University. U.S. patent application number 63/135,062.

Technical Data for Mpro 61

M. Wt	565.38
Formula	C₂₈H₁₉Cl₂FN₄O₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2679814-93-6
PubChem ID	156587560
InChi Key	KIJKUSPNZALBLD-UHFFFAOYSA-N
Smiles	CN1C=C(C2=CN(C3=CN=CC=C3)C(C(C4=CC(OCC5=C(C=CC=C5)Cl)=C(C(Cl)=C4)F)=C2)=O)C(NC1=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mpro 61

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.31	20

Preparing Stock Solutions for Mpro 61

The following data is based on the product molecular weight 565.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.84 mL	44.22 mL	88.44 mL
1 mM	1.77 mL	8.84 mL	17.69 mL
2 mM	0.88 mL	4.42 mL	8.84 mL
10 mM	0.18 mL	0.88 mL	1.77 mL

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References for Mpro 61

References are publications that support the biological activity of the product.

Zhang Optimization of triarylpyridinone inhibitors of the main protease of SARS-CoV-2 to low-nanomolar antiviral potency. ACS Med.Chem.Lett. 2021 PMID: 34408808