Mps1-IN-1 dihydrochloride

Name: Mps1-IN-1 dihydrochloride
Brand: Tocris Bioscience
SKU: 5142

Tocris Bioscience, part of Bio-Techne | Catalog # 5142

Citations (2)

COA / SDS

Selective Mps1 kinase inhibitor

Key Product Details

Description:	Selective Mps1 kinase inhibitor
Chemical Name:	1-[3-Methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-4-piperidinol dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	608.58

View Full Technical Details for Mps1-IN-1 dihydrochloride

Technical Data
Citations

Biological Activity for Mps1-IN-1 dihydrochloride

Mps1-IN-1 dihydrochloride is a selective monopolar spindle 1 (Mps1) kinase inhibitor (IC₅₀ = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Mps1-IN-1 is reviewed on the chemical probes website.

Technical Data for Mps1-IN-1 dihydrochloride

M. Wt	608.58
Formula	C₂₈H₃₃N₅O₄S.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1883548-93-3
PubChem ID	91691119
InChi Key	HFJLUXGXTPNYTQ-UHFFFAOYSA-N
Smiles	CC(C)S(C(C=CC=C3)=C3NC1=CC(NC4=C(OC)C=C(N5CCC(O)CC5)C=C4)=NC2=C1C=CN2)(=O)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mps1-IN-1 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	60.86	100
	DMSO	60.86	100

Preparing Stock Solutions for Mps1-IN-1 dihydrochloride

The following data is based on the product molecular weight 608.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.64 mL	8.22 mL	16.43 mL
5 mM	0.33 mL	1.64 mL	3.29 mL
10 mM	0.16 mL	0.82 mL	1.64 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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References for Mps1-IN-1 dihydrochloride

References are publications that support the biological activity of the product.

Miduturu High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem.Biol. 2011 PMID: 21802008
Lan and Cleveland A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell Biol. 2010 PMID: 20624898
Kwiatkowski Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol. 2010 PMID: 20383151