MRS 1334

Name: MRS 1334
Brand: Tocris Bioscience
SKU: 1385

Tocris Bioscience, part of Bio-Techne | Catalog # 1385

Citations (15)

COA / SDS

Potent, highly selective hA3 antagonist

Key Product Details

Description:	Potent, highly selective hA₃ antagonist
Chemical Name:	1,4-Dihydro-2-methyl-6-phenyl-4-(phenylethynyl)-3,5-pyridinedicarboxylic acid 3-ethyl-5-[(3-nitrophenyl)methyl] ester
Purity:	≥98% (HPLC)
Molecular Weight:	522.56

View Full Technical Details for MRS 1334

Technical Data
Citations

Biological Activity for MRS 1334

MRS 1334 is a potent and highly selective antagonist for the human adenosine A₃ receptor. K_i values are 2.69 nM at hA₃, and > 100 μM at rat A₁ and rat A_2A receptors.

Licensing Information

Sold with the permission of the NIH, US Patent 60/029,855

Technical Data for MRS 1334

M. Wt	522.56
Formula	C₃₁H₂₆N₂O₆
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	192053-05-7
PubChem ID	4519822
InChi Key	QFLOJAMZLQXHFS-UHFFFAOYSA-N
Smiles	CCOC(=O)C1=C(C)NC(C2=CC=CC=C2)=C(C1C#CC1=CC=CC=C1)C(=O)OCC1=CC=C(C=C1)N(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 1334

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	52.26	100

Preparing Stock Solutions for MRS 1334

The following data is based on the product molecular weight 522.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.91 mL	9.57 mL	19.14 mL
5 mM	0.38 mL	1.91 mL	3.83 mL
10 mM	0.19 mL	0.96 mL	1.91 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for MRS 1334

References are publications that support the biological activity of the product.

Li Structure-activity relationships and molecular modeling of 3,5-diacyl-2,4-dialkylpyridine derivatives as selective A₃ adenosine receptor antagonists. J.Med.Chem. 1998 PMID: 9703464
Corriden Adenosine-A₃ receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO.Rep. 2013 PMID: 23817552
Baraldi and Borea New potent and selective human adenosine A₃ receptor antagonists. TiPS 2000 PMID: 11121831