MRS 2365

Name: MRS 2365
Brand: Tocris Bioscience
SKU: 2157

Tocris Bioscience, part of Bio-Techne | Catalog # 2157

Citations (82)

COA / SDS

Highly potent and selective P2Y1 agonist

Key Product Details

Description:	Highly potent and selective P2Y₁ agonist
Chemical Name:	[[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	549.28

View Full Technical Details for MRS 2365

Technical Data
Citations

Biological Activity for MRS 2365

MRS 2365 is a highly potent, selective P2Y₁ receptor agonist (EC₅₀ = 0.4 nM). Displays no activity at P2Y₁₂ receptors and only very low agonist activity at P2Y₁₃ receptors (at concentrations up to 1 μM). Increases the upregulation of NTPDase1 by ATPγS.

Licensing Information

Sold under license from the NIH, US Patent 10/169975

Technical Data for MRS 2365

M. Wt	549.28
Formula	C₁₃H₁₆N₅O₉P₂SNa₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	73755043
InChi Key	ZYPJOXVKTCEBCA-PVMCGCOJSA-K
Smiles	[Na+].[Na+].[Na+].CSC1=NC(N)=C2N=CN(C3[C@H]4C[C@@]4(COP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]3O)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 2365

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

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References for MRS 2365

References are publications that support the biological activity of the product.

Chhatriwala Induction of novel agonist selectivity for the ADP-activated P2Y₁ receptor versus the ADP-activated P2Y₁₂ and P2Y₁₃ receptors by conformational constraint of an ADP analog. J.Pharmacol.Exp.Ther. 2004 PMID: 15345752
Lu Stimulation of the P2Y₁ receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 2007 PMID: 17626796
Ravi Adenine nucleotide analogues locked in a northern methanocarba conformation: enhanced stability and potency as P2Y₁ receptor agonists. J.Med.Chem. 2002 PMID: 11985476