MRS 2578

Name: MRS 2578
Brand: Tocris Bioscience
SKU: 2146

Tocris Bioscience, part of Bio-Techne | Catalog # 2146

(2)

Citations (72)

COA / SDS

Selective P2Y6 antagonist

Key Product Details

Chemical Name:	N,N''-1,4-Butanediylbis[N'-(3-isothiocyanatophenyl)thiourea
Purity:	≥95%
Molecular Weight:	472.66 kDa

View Full Technical Details for MRS 2578

Technical Data
Citations / Reviews (2)

Biological Activity for MRS 2578

MRS 2578 is a selective antagonist of P2Y₆ nucleotide receptors; IC₅₀ values are 37 and 98 nM at human and rat P2Y₆ receptors respectively. Displays no activity at P2Y₁, P2Y₂, P2Y₄ and P2Y₁₁ receptors (IC₅₀ > 10 μM). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.

Technical Data for MRS 2578

M. Wt	472.66 kDa
Formula	C₂₀H₂₀N₆S₄
Storage	Store at -20°C
Purity	≥95%
CAS Number	711019-86-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 2578

Solubility

Soluble Soluble to 50 mM in DMSO

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References for MRS 2578

References are publications that support the biological activity of the product.

Neniskyte U, Vilalta A, Brown G Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis. FEBS Lett, 2014;588(17):2952-6. 2014 PMID: 24911209
Balasubramanian R, Robaye B, Boeynaems J, Jacobson K Enhancement of glucose uptake in mouse skeletal muscle cells and adipocytes by P2Y6 receptor agonists. PLoS ONE, 2014;9(12):e116203. 2014 PMID: 25549240
Kukulski et al. Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo. J.Leukoc.Biol., 2007;81:1269 PMID: 17322022
Mamedova et al. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y₆ nucleotide receptors. Biochem.Pharmacol., 2004;67:1763 PMID: 15081875
Koizumi et al. UDP acting at P2Y₆ receptors is a mediator of microglial phagocytosis. Nature, 2007;446:1091 PMID: 17410128