MS 147

Name: MS 147
Brand: Tocris Bioscience
SKU: 8077

Tocris Bioscience, part of Bio-Techne | Catalog # 8077

COA / SDS

PRC1 Degrader (PROTAC®); degrades BMI1 and RING1B

Key Product Details

Description:	PRC1 Degrader (PROTAC^®); degrades BMI1 and RING1B
Chemical Name:	(2S,4R)-1-((S)-2-(7-(5-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)phenyl)piperazin-1-yl)pentanamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Purity:	≥97% (HPLC)

View Full Technical Details for MS 147

Technical Data
Citations

Biological Activity for MS 147

MS 147 is a polycomb repressive complex 1 (PRC1) Degrader (PROTAC^®) (K_d values are 450 nM and 3 μM for VHL and EED, respectively). Comprises an EED binder (EED 226, Cat. No. 7762) joined by a linker to a VHL E3 ligase ligand. MS 147 preferentially degrades BMI1 and RING1B and reduces H2AK119ub in K562 cells. Inhibits proliferation in cancer cell lines that are insensitive to EZH2 knockout or EED/PRC2 Degraders.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Important Information

This product is sold as an HCl salt. The stoichiometry of the salt and hydration levels vary from batch to batch. It is sold in gross weight and the batch specific Molecular Weight is available on the Certificate of Analysis.

Technical Data for MS 147

Formula	C₅₄H₇₀N₁₂O₆S.xHCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
InChi Key	WZUKNVLQEQHTMY-RTJWYONCSA-N
Smiles	CC1=C(C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCCCNC(CCCCN4CCN(C5=CC=C(C6=CN=C(NCC7=CC=CO7)N8C6=NN=C8)C=C5)CC4)=O)=O)C(C)(C)C)=O)=O)C=C2)SC=N1.Cl
M. Wt	1015.29 (Free Base)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MS 147

Solubility

Soluble to 50mg/ml in DMSO

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for MS 147

References are publications that support the biological activity of the product.

Park Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy. Adv.Sci. (Weinh.) 2023 PMID: 36737841