MS 154N

Name: MS 154N
Brand: Tocris Bioscience
SKU: 7396

Tocris Bioscience, part of Bio-Techne | Catalog # 7396

COA / SDS

Negative control for MS 154 (Cat No. 7395)

Key Product Details

Description:	Negative control for MS 154 (Cat No. 7395)
Chemical Name:	3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide
Purity:	≥98% (HPLC)
Molecular Weight:	915.46

View Full Technical Details for MS 154N

Technical Data
Citations

Biological Activity for MS 154N

MS 154N is a negative control for MS 154 (Cat No. 7395). The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (K_d values are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Technical Data for MS 154N

M. Wt	915.46
Formula	C₄₇H₅₆ClFN₈O₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2675490-97-6
PubChem ID	155515813
InChi Key	XFUDPXQGWCYCCR-UHFFFAOYSA-N
Smiles	COC1=CC2=C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)C=C1OCCCN4CCN(CC4)CCC(NCCCCCCCCOC5=C6C(N(C(C6=CC=C5)=O)C7CCC(N(C)C7=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MS 154N

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	91.55	100

Preparing Stock Solutions for MS 154N

The following data is based on the product molecular weight 915.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.09 mL	5.46 mL	10.92 mL
5 mM	0.22 mL	1.09 mL	2.18 mL
10 mM	0.11 mL	0.55 mL	1.09 mL
50 mM	0.02 mL	0.11 mL	0.22 mL

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References for MS 154N

References are publications that support the biological activity of the product.

Cheng Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders. J.Med.Chem. 2020 PMID: 31895569