Muscimol

Name: Muscimol
Brand: Tocris Bioscience
SKU: 0289
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0289

(1)

Citations (378)

COA / SDS

Potent GABAA agonist; also GABAA-ρ partial agonist

Key Product Details

Description:	Potent GABA_A agonist; also GABA_A-ρ partial agonist
Chemical Name:	5-Aminomethyl-3-hydroxyisoxazole
Purity:	≥98%
Molecular Weight:	114.1

View Full Technical Details for Muscimol

Technical Data
Citations / Reviews (1)

Biological Activity for Muscimol

Muscimol is a potent GABA_A receptor agonist and partial GABA_A-ρ receptor agonist. Inhibits memory retention and attenuates airway constriction in vivo.

Technical Data for Muscimol

M. Wt	114.1
Formula	C₄H₆N₂O₂
Storage	Store at RT
Purity	≥98%
CAS Number	2763-96-4
PubChem ID	4266
InChi Key	ZJQHPWUVQPJPQT-UHFFFAOYSA-N
Smiles	NCC1=CC(O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Muscimol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	11.41	100

Preparing Stock Solutions for Muscimol

The following data is based on the product molecular weight 114.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	8.76 mL	43.82 mL	87.64 mL
5 mM	1.75 mL	8.76 mL	17.53 mL
10 mM	0.88 mL	4.38 mL	8.76 mL
50 mM	0.18 mL	0.88 mL	1.75 mL

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References for Muscimol

References are publications that support the biological activity of the product.

Johnstone GABA_C receptors: relatively simple transmitter-gated ion channels? TiPS 1996 PMID: 8885697
Johnston Central actions of ibotenic acid and muscimol. Biochem.Pharmacol. 1968 PMID: 5752907
Gleason The GABA_A agonist muscimol attenuates induced airway constriction in guinea pigs in vivo. J.Appl.Physiol. 2009 PMID: 19213928
Jafari-Sabet and Jannat-Dastjerdi Muscimol state-dependent memory: involvement of dorsal hippocampal μ-opioid receptors. Behav.Brain Res. 2009 PMID: 19447274
Akhondzadeh and Stone Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABA_A but not glutamate receptors. Br.J.Pharmacol. 1995 PMID: 7582468