N-Acetylpuromycin

Name: N -Acetylpuromycin
Brand: Tocris Bioscience
SKU: 5679

Tocris Bioscience, part of Bio-Techne | Catalog # 5679

Citations (2)

COA / SDS

Downregulates SnoN and Ski protein expression; promotes TGF-β signaling

Key Product Details

Description:	Downregulates SnoN and Ski protein expression; promotes TGF-β signaling
Chemical Name:	3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine
Purity:	≥98% (HPLC)
Molecular Weight:	513.55

View Full Technical Details for N-Acetylpuromycin

Technical Data
Citations

Biological Activity for N-Acetylpuromycin

N-Acetylpuromycin downregulates SnoN and Ski protein expression; promotes TGF-β signaling, independently of MAPK activation. Does not bind ribosomes or block protein synthesis.

Technical Data for N-Acetylpuromycin

M. Wt	513.55
Formula	C₂₄H₃₁N₇O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	22852-13-7
PubChem ID	46173769
InChi Key	LADKVYSQIGJMFP-IYRMOJGWSA-N
Smiles	O[C@@H]1[C@H](NC([C@@H](NC(C)=O)CC4=CC=C(OC)C=C4)=O)[C@@H](CO)O[C@H]1N3C2=NC=NC(N(C)C)=C2N=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for N-Acetylpuromycin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.35	100
	1eq. HCl	51.35	100

Preparing Stock Solutions for N-Acetylpuromycin

The following data is based on the product molecular weight 513.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.74 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for N-Acetylpuromycin

References are publications that support the biological activity of the product.

Hernández-Damián Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals. Biochim.Biophys.Acta. 2013 PMID: 23872350