NAADP tetrasodium salt

Name: NAADP tetrasodium salt
Brand: Tocris Bioscience
SKU: 3905

Tocris Bioscience, part of Bio-Techne | Catalog # 3905

Citations (6)

COA / SDS

Ca2+ mobilizing agent

Key Product Details

Chemical Name:	Nicotinic acid adenine dinucleotide phosphate tetrasodium salt
Purity:	≥98%
Molecular Weight:	832.32 kDa

View Full Technical Details for NAADP tetrasodium salt

Technical Data
Citations

Biological Activity for NAADP tetrasodium salt

NAADP tetrasodium salt is a Ca²⁺ mobilizing agent. Initiates Ca²⁺ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca²⁺ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca²⁺ from acidic organelles.

Technical Data for NAADP tetrasodium salt

M. Wt	832.32 kDa
Formula	C₂₁H₂₃N₆Na₄O₁₈P₃
Storage	Store at -20°C
Purity	≥98%

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NAADP tetrasodium salt

Solubility

Soluble Soluble to 50 mM in water

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References for NAADP tetrasodium salt

References are publications that support the biological activity of the product.

Y Miyatake, T Yamano, R Hanayama Myoferlin-Mediated Lysosomal Exocytosis Regulates Cytotoxicity by Phagocytes J. Immunol., 2018;0(0):. 2018 PMID: 30333125
Calcraft PJ, Ruas M, Pan Z et al. NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 2009-05-01 PMID: 19387438
Dammerman et al. NAADP-mediated Ca²⁺ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist. Proc.Natl.Acad.Sci., 2009;106:10678
Galion NAADP, a new intracellular messenger that mobilizes Ca²⁺ from acidic stores. Biochem.Soc.Transactions, 2006;34:922