Narciclasine

Name: Narciclasine
Brand: Tocris Bioscience
SKU: 3715

Tocris Bioscience, part of Bio-Techne | Catalog # 3715

Citations (7)

COA / SDS

Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

Key Product Details

Description:	Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression
Chemical Name:	(2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	307.26

View Full Technical Details for Narciclasine

Technical Data
Citations

Biological Activity for Narciclasine

Narciclasine is an exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC₅₀ = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.

Technical Data for Narciclasine

M. Wt	307.26
Formula	C₁₄H₁₃NO₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	29477-83-6
PubChem ID	72376
InChi Key	LZAZURSABQIKGB-AEKGRLRDSA-N
Smiles	OC1=C(C(N[C@]4([H])C3=C[C@H](O)[C@@H](O)[C@H]4O)=O)C3=CC2=C1OCO2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Narciclasine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.73	100

Preparing Stock Solutions for Narciclasine

The following data is based on the product molecular weight 307.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.25 mL	16.27 mL	32.55 mL
5 mM	0.65 mL	3.25 mL	6.51 mL
10 mM	0.33 mL	1.63 mL	3.25 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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References for Narciclasine

References are publications that support the biological activity of the product.

Ingrassia Structure-activity relationship analysis of novel derivatives of narciclasine (an Amaryllidaceae isocarbostyril derivative) as potential anticancer agents. J.Med.Chem. 2009 PMID: 19199649
Lefranc Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol.Cancer Ther. 2009 PMID: 19531573
Dumont The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts. Neoplasia 2007 PMID: 17898872