Nebivolol hydrochloride

Name: Nebivolol hydrochloride
Brand: Tocris Bioscience
SKU: 3517

Tocris Bioscience, part of Bio-Techne | Catalog # 3517

Citations (1)

COA / SDS

Highly selective β1-adrenoceptor antagonist

Key Product Details

Description:	Highly selective β₁-adrenoceptor antagonist
Chemical Name:	(±)-[2R(1S5S(S))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
Purity:	≥98% (HPLC)
Molecular Weight:	441.9

View Full Technical Details for Nebivolol hydrochloride

Technical Data
Citations

Biological Activity for Nebivolol hydrochloride

Nebivolol hydrochloride is a highly selective β₁-adrenoceptor antagonist (K_i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β₁, 5-HT_1A, β₂, 5-HT₂, α₁, H₁ and D₂ receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC₅₀ = 11.36 μM in renal arteries) and displays antihypertensive activity in vivo. GRK/β -arrestin biased agonist at the β2 adrenoceptor.

Compound Libraries for Nebivolol hydrochloride

Nebivolol hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Nebivolol hydrochloride

M. Wt	441.9
Formula	C₂₂H₂₅F₂NO₄.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	152520-56-4
PubChem ID	11812257
InChi Key	JWEXHQAEWHKGCW-VCVZPGOSSA-N
Smiles	FC(C=C4)=CC3=C4O[C@@](CC3)([H])[C@H](O)CNC[C@@H](O)[C@]2([H])CCC1=CC(F)=CC=C1O2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nebivolol hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.19	100
	ethanol	4.42	10

Preparing Stock Solutions for Nebivolol hydrochloride

The following data is based on the product molecular weight 441.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.31 mL	22.63 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for Nebivolol hydrochloride

References are publications that support the biological activity of the product.

Georgescu Nebivolol induces a hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of beta-2-adrenoceptors. Pharmacology 2008 PMID: 17952013
Erickson The beta -blocker nebi. Is a GRK/ beta -arrestin biased agonist. PLoS One 2013 PMID: 23977191
Pauwels The receptor binding profile of the new antihypertensive agent nebi. and its stereoisomers compared with various β-adrenergic blockers. Mol.Pharmacol. 1988 PMID: 2462161