Necrosulfonamide

Name: Necrosulfonamide
Brand: Tocris Bioscience
SKU: 5025
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5025

(1)

Citations (48)

COA / SDS

Necroptosis inhibitor; also inhibits pyroptosis

Key Product Details

Description:	Necroptosis inhibitor; also inhibits pyroptosis
Chemical Name:	(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
Purity:	≥98% (HPLC)
Molecular Weight:	461.47

View Full Technical Details for Necrosulfonamide

Technical Data
Citations / Reviews (1)

Biological Activity for Necrosulfonamide

Necrosulfonamide is a necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.

Technical Data for Necrosulfonamide

M. Wt	461.47
Formula	C₁₈H₁₅N₅O₆S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1360614-48-7
PubChem ID	1566236
InChi Key	FNPPHVLYVGMZMZ-XBXARRHUSA-N
Smiles	O=C(NC2=CC=C(S(NC3=C(OC)N=CC=N3)(=O)=O)C=C2)/C=C/C1=CC=C([N+]([O-])=O)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Necrosulfonamide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.23	20

Preparing Stock Solutions for Necrosulfonamide

The following data is based on the product molecular weight 461.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.83 mL	54.17 mL	108.35 mL
1 mM	2.17 mL	10.83 mL	21.67 mL
2 mM	1.08 mL	5.42 mL	10.83 mL
10 mM	0.22 mL	1.08 mL	2.17 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Necrosulfonamide

References are publications that support the biological activity of the product.

Pandeya Gasdermin D (GSDMD) as a new target for the treatment of infection. Medchemcomm 2019 PMID: 31191857
Sun Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012 PMID: 22265413
Kreuzaler Killing a cancer: what are the alternatives? Nat.Rev.Cancer. 2012 PMID: 22576162
Zhou New components of the necroptotic pathway. Protein Cell 2012 PMID: 23073834