Nemonapride

Name: Nemonapride
Brand: Tocris Bioscience
SKU: 1746

Tocris Bioscience, part of Bio-Techne | Catalog # 1746

Citations (6)

COA / SDS

Highly potent D2-like antagonist; also 5-HT1A agonist

Key Product Details

Chemical Name:	cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide
Purity:	≥99%
Molecular Weight:	387.91 kDa

View Full Technical Details for Nemonapride

Technical Data
Citations

Biological Activity for Nemonapride

Nemonapride is a highly potent dopamine D₂-like receptor antagonist; selective over D₁-like receptors (K_i values are 0.1 and 740 nM for D₂-like and D₁-like receptors respectively). Also potent 5-HT_1A receptor agonist (IC₅₀ = 34 nM) and has affinity for sigma receptors.

Technical Data for Nemonapride

M. Wt	387.91 kDa
Formula	C₂₁H₂₆ClN₃O₂
Storage	Store at RT
Purity	≥99%
CAS Number	75272-39-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nemonapride

Solubility

Soluble Soluble to 20 mM in ethanol and to 25 mM in DMSO

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References for Nemonapride

References are publications that support the biological activity of the product.

Terai et al. Selective binding of YM-09151-2, a new potent neuroleptic, to D₂-DArgic receptors. Jpn.J.Pharmacol., 1983;33:749 PMID: 6138453
Ujike et al. [³H]YM-09151-2 (nemonapride), a potent radioligand for both sigma₁ and sigma₂ receptor subtypes. Neuroreport, 1996;7:1057 PMID: 8804051
Assie et al. 5-HT_1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and cloz. Eur.J.Pharmacol., 1997;334:141 PMID: 9369342