Nemonapride

Name: Nemonapride
Brand: Tocris Bioscience
SKU: 1746

Tocris Bioscience, part of Bio-Techne | Catalog # 1746

Citations (6)

COA / SDS

Highly potent D2-like antagonist; also 5-HT1A agonist

Key Product Details

Description:	Highly potent D₂-like antagonist; also 5-HT_1A agonist
Alternative Names:	YM 09151,YM 09151-2
Chemical Name:	cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	387.91

View Full Technical Details for Nemonapride

Technical Data
Citations

Biological Activity for Nemonapride

Nemonapride is a highly potent dopamine D₂-like receptor antagonist; selective over D₁-like receptors (K_i values are 0.1 and 740 nM for D₂-like and D₁-like receptors respectively). Also potent 5-HT_1A receptor agonist (IC₅₀ = 34 nM) and has affinity for sigma receptors.

Compound Libraries for Nemonapride

Nemonapride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Nemonapride

M. Wt	387.91
Formula	C₂₁H₂₆ClN₃O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	75272-39-8
PubChem ID	76968489
InChi Key	QCYCDKUNJFKYEI-ZVWWNKPMSA-N
Smiles	O=C(C3=C(OC)C=C(NC)C(Cl)=C3)N[C@@H]1CCN(CC2=CC=CC=C2)[C@@H]1C.O=C(C6=C(OC)C=C(NC)C(Cl)=C6)N[C@H]4CCN(CC5=CC=CC=C5)[C@H]4C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nemonapride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	7.76	20
	DMSO	9.7	25

Preparing Stock Solutions for Nemonapride

The following data is based on the product molecular weight 387.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.31 mL	51.56 mL	103.12 mL
1.25 mM	2.06 mL	10.31 mL	20.62 mL
2.5 mM	1.03 mL	5.16 mL	10.31 mL
12.5 mM	0.21 mL	1.03 mL	2.06 mL

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Reconstitution Calculator

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References for Nemonapride

References are publications that support the biological activity of the product.

Terai Selective binding of YM-09151-2, a new potent neuroleptic, to D₂-DArgic receptors. Jpn.J.Pharmacol. 1983 PMID: 6138453
Ujike [³H]YM-09151-2 (nemonapride), a potent radioligand for both sigma₁ and sigma₂ receptor subtypes. Neuroreport 1996 PMID: 8804051
Assie 5-HT_1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and cloz. Eur.J.Pharmacol. 1997 PMID: 9369342