NF 546

Name: NF 546
Brand: Tocris Bioscience
SKU: 3892
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3892

(1)

Citations (20)

COA / SDS

Selective P2Y11 agonist

Key Product Details

Description:	Selective P2Y₁₁ agonist
Chemical Name:	4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid tetrasodium salt
Purity:	≥95% (HPLC)
Molecular Weight:	1180.74

View Full Technical Details for NF 546

Technical Data
Citations / Reviews (1)

Biological Activity for NF 546

NF 546 is a P2Y₁₁ agonist (pEC₅₀ = 6.27). Exhibits selectivity for P2Y₁₁ over a range of P2Y and P2X receptors. Also inhibits DNA-binding activity of HMGA2 (IC₅₀ = 5.49 μM).

Technical Data for NF 546

M. Wt	1180.74
Formula	C₄₇H₄₄N₆Na₄O₁₇P₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1006028-37-0
PubChem ID	73755075
InChi Key	GSMUPMANKNAMAS-UHFFFAOYSA-J
Smiles	[Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC=CC(NC(=O)NC2=CC=CC(=C2)C(=O)NC2=C(C)C=CC(=C2)C(=O)NC2=CC=C(CP(O)([O-])=O)C=C2CP(O)([O-])=O)=C1)C(=O)NC1=C(CP(O)([O-])=O)C=C(CP(O)([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NF 546

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	11.81	10 with gentle warming

Preparing Stock Solutions for NF 546

The following data is based on the product molecular weight 1180.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	8.47 mL	42.35 mL	84.69 mL
0.5 mM	1.69 mL	8.47 mL	16.94 mL
1 mM	0.85 mL	4.23 mL	8.47 mL
5 mM	0.17 mL	0.85 mL	1.69 mL

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References for NF 546

References are publications that support the biological activity of the product.

Su Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci.Rep. 2020 PMID: 33139812
Meis NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk J.Pharmacol.Exp.Ther. 2010 PMID: 19815812