Nimodipine

Name: Nimodipine
Brand: Tocris Bioscience
SKU: 0600
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0600

(1)

Citations (195)

COA / SDS

CaV1.x blocker

Key Product Details

Description:	Ca_V1.x blocker
Chemical Name:	1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methyloxyethyl 1-methylethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	418.45

View Full Technical Details for Nimodipine

Technical Data
Citations / Reviews (1)

Biological Activity for Nimodipine

Nimodipine is a L-type Ca²⁺ channel blocker. Induces autophagy. Nimodipine is modulating pericytes and other inflammation signals like Hypoxia and leukocyte stalling to improve cognitive function in Alzheimer’s disease. Nimodipine reduces pericytes and other inflammation signals like hypoxia and leukocyte stalling and improves cognitive function in Alzheimer's disease model mice.

Technical Data for Nimodipine

M. Wt	418.45
Formula	C₂₁H₂₆N₂O₇
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	66085-59-4
PubChem ID	4497
InChi Key	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Smiles	COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nimodipine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.84	100

Preparing Stock Solutions for Nimodipine

The following data is based on the product molecular weight 418.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.95 mL	23.90 mL
5 mM	0.48 mL	2.39 mL	4.78 mL
10 mM	0.24 mL	1.19 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Reconstitution Calculator

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References for Nimodipine

References are publications that support the biological activity of the product.

Korte Inhibiting Ca2+ channels in Alzheimer's disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia. Nat. Neurosci. 2024 PMID: 39294491
Fleming Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 2011 PMID: 21164513
Izquierdo Nimodipine and the recovery of memory. TiPS 1990 PMID: 2203191
Kappelle Beneficial effect of the Ca²⁺ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat. Br.J.Pharmacol. 1994 PMID: 8019766
Batuecas Effects of chronic nimod. on working memory of old rats in relation to defects in synaptosomal calcium homeostasis. Eur.J.Pharmacol. 1998 PMID: 9696401

Product Documents for Nimodipine

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Nimodipine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov