NS 1643

Name: NS 1643
Brand: Tocris Bioscience
SKU: 3062
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3062

(1)

Citations (9)

COA / SDS

KV11.1 (hERG) channel activator; antiarrhythmic

Key Product Details

Description:	K_V11.1 (hERG) channel activator; antiarrhythmic
Chemical Name:	N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
Purity:	≥98% (HPLC)
Molecular Weight:	380.24

View Full Technical Details for NS 1643

Technical Data
Citations / Reviews (1)

Biological Activity for NS 1643

NS 1643 is a human ether-a-go-go related gene (hERG) K_V11.1 channel activator (EC₅₀ = 10.5 μM). Exhibits different molecular mechanisms of action at K_V11.1 (hERG1) and K_V11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro.

Technical Data for NS 1643

M. Wt	380.24
Formula	C₁₅H₁₀F₆N₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	448895-37-2
PubChem ID	10177784
InChi Key	NJFVQMRYJZHGME-UHFFFAOYSA-N
Smiles	OC1=C(NC(NC2=C(O)C=CC(C(F)(F)F)=C2)=O)C=C(C(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 1643

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	38.02	100
	DMSO	9.51	25

Preparing Stock Solutions for NS 1643

The following data is based on the product molecular weight 380.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.63 mL	13.15 mL	26.30 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
10 mM	0.26 mL	1.31 mL	2.63 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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Reconstitution Calculator

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References for NS 1643

References are publications that support the biological activity of the product.

Casis Mechanism of action of a novel human ether-a-go-ao related gene channel activator. Mol.Pharmacol. 2006 PMID: 16284303
Elmedyb Activation of ERG2 potassium channel by the diphenylurea NS1643. Neuropharmacology 2007 PMID: 17610913
Hansen Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol.Pharmacol. 2006 PMID: 16219910