NS 2028

Name: NS 2028
Brand: Tocris Bioscience
SKU: 4517

Tocris Bioscience, part of Bio-Techne | Catalog # 4517

Citations (7)

COA / SDS

Potent soluble guanylyl cyclase (sGC) inhibitor

Key Product Details

Description:	Potent soluble guanylyl cyclase (sGC) inhibitor
Chemical Name:	8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	269.05

View Full Technical Details for NS 2028

Technical Data
Citations

Biological Activity for NS 2028

NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (K_i = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC₅₀ values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).

Compound Libraries for NS 2028

NS 2028 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NS 2028

M. Wt	269.05
Formula	C₉H₅BrN₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	204326-43-2
PubChem ID	4551
InChi Key	MUDRLQRJCGJJTB-UHFFFAOYSA-N
Smiles	BrC1=CC=C(OCC(N23)=NOC3=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 2028

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.91	100
	ethanol	5.38	20

Preparing Stock Solutions for NS 2028

The following data is based on the product molecular weight 269.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.72 mL	18.58 mL	37.17 mL
5 mM	0.74 mL	3.72 mL	7.43 mL
10 mM	0.37 mL	1.86 mL	3.72 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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Reconstitution Calculator

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References for NS 2028

References are publications that support the biological activity of the product.

Morbidelli The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am.J.Physiol.Regul.Integr.Comp.Physiol. 2010 PMID: 20032260
Olesen Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br.J.Pharmacol. 1998 PMID: 9489619
von Wantoch Rekowski Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase. Bioorg.Med.Chem. 2010 PMID: 20036129