NS 309

Name: NS 309
Brand: Tocris Bioscience
SKU: 3895
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3895

(1)

Citations (52)

COA / SDS

Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels

Key Product Details

Description:	Positive modulator of K_Ca2 (SK) and K_Ca3.1 (IK) channels
Chemical Name:	6,7-Dichloro-1H-indole-2,3-dione 3-oxime
Purity:	≥98% (HPLC)
Molecular Weight:	231.04

View Full Technical Details for NS 309

Technical Data
Citations / Reviews (1)

Biological Activity for NS 309

NS 309 is a positive modulator of small- and intermediate- conductance Ca²⁺-activated K⁺ channels (K_Ca2 and K_Ca3.1 channels); increases Ca²⁺ sensitivity. Displays no activity at BK channels.

Technical Data for NS 309

M. Wt	231.04
Formula	C₈H₄Cl₂N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	18711-16-5
PubChem ID	11637204
InChi Key	CVOUSAVHMDXCKG-UHFFFAOYSA-N
Smiles	ClC1=C2C(C(C(N2)=O)=NO)=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 309

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.1	100

Preparing Stock Solutions for NS 309

The following data is based on the product molecular weight 231.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.33 mL	21.64 mL	43.28 mL
5 mM	0.87 mL	4.33 mL	8.66 mL
10 mM	0.43 mL	2.16 mL	4.33 mL
50 mM	0.09 mL	0.43 mL	0.87 mL

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Reconstitution Calculator

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References for NS 309

References are publications that support the biological activity of the product.

Strobaek Activation of human IK and SK Ca²⁺-activated K⁺ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim.Biophys.Acta 2004 PMID: 15471565
Morimura Voltage-dependent Ca²⁺-channel block by openers of intermediate and small conductance Ca²⁺-activated K⁺ channels in urinary bladder smooth muscle cells. J.Pharm.Sci. 2006 PMID: 16518073
Grgic Endothelial Ca²⁺-activated K⁺ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery. Br.J.Pharmacol. 2009 PMID: 19302590