NS 383

Name: NS 383
Brand: Tocris Bioscience
SKU: 5927

Tocris Bioscience, part of Bio-Techne | Catalog # 5927

COA / SDS

ASIC blocker; active in vivo

Key Product Details

Description:	ASIC blocker; active in vivo
Chemical Name:	8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
Molecular Weight:	321.37

View Full Technical Details for NS 383

Technical Data
Citations

Biological Activity for NS 383

NS 383 is an ASIC blocker (IC₅₀ values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC₅₀ value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC₅₀ values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC_5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.

Technical Data for NS 383

M. Wt	321.37
Formula	C₁₉H₁₉N₃O₂
Storage	Store at -20°C
CAS Number	309711-59-9
PubChem ID	135418391
InChi Key	CHVQAXYXYIDNDC-UHFFFAOYSA-N
Smiles	CCN1CCC2=C(C3=C(/C(C(N3)=O)=N\O)C=C2C4=CC=CC=C4)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 383

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	1.61	5

Preparing Stock Solutions for NS 383

The following data is based on the product molecular weight 321.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	62.23 mL	311.17 mL	622.34 mL
0.25 mM	12.45 mL	62.23 mL	124.47 mL
0.5 mM	6.22 mL	31.12 mL	62.23 mL
2.5 mM	1.24 mL	6.22 mL	12.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for NS 383

References are publications that support the biological activity of the product.

Munro NS383 Selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats. CNS Neurosci.Ther. 2016 PMID: 26663905