NS 5806

Name: NS 5806
Brand: Tocris Bioscience
SKU: 4166
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4166

(1)

Citations (10)

COA / SDS

KV4.3 channel activator

Key Product Details

Description:	K_V4.3 channel activator
Chemical Name:	N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea
Purity:	≥99% (HPLC)
Molecular Weight:	574.07

View Full Technical Details for NS 5806

Technical Data
Citations / Reviews (1)

Biological Activity for NS 5806

NS 5806 is a K_V4.3 channel activator; mediates the transient outward K⁺ current (I_to). Increases I_Kv4.3 peak current amplitude in CHO-K1 cells expressing K_V4.3 and KChIP2 (EC₅₀ = 5.3 μM). Inhibits K_V1.4-mediated currents independently of KChIP2. Also slows the decay of K_V4.2 and K_V4.3 currents in the presence of KChIP2.

Compound Libraries for NS 5806

NS 5806 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NS 5806

M. Wt	574.07
Formula	C₁₆H₈Br₂F₆N₆O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	426834-69-7
PubChem ID	11642685
InChi Key	UZWJWROOLOOCPQ-UHFFFAOYSA-N
Smiles	BrC1=CC(Br)=CC(C2=NN=NN2)=C1NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 5806

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	57.41	100
	ethanol	28.7	50

Preparing Stock Solutions for NS 5806

The following data is based on the product molecular weight 574.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.74 mL	8.71 mL	17.42 mL
5 mM	0.35 mL	1.74 mL	3.48 mL
10 mM	0.17 mL	0.87 mL	1.74 mL
50 mM	0.03 mL	0.17 mL	0.35 mL

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Reconstitution Calculator

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References for NS 5806

References are publications that support the biological activity of the product.

Calloe Differential effects of the transient outward K⁺ current activator NS5806 in the canine left ventricle. J.Mol.Cell.Cardiol. 2010 PMID: 19632239
Lundby Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2. Br.J.Pharmacol. 2010 PMID: 20649599
Calloe A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. Cardiovasc.Res. 2009 PMID: 19073629